Solid state charecterization

As the majority of drugs are administered as solids, solid-state properties of the active ingredient significantly influence the performance of the final product.

Most substances can crystallize as different solid forms (polymorphs, hydrates, solvates, co-crystals). Furthermore, a large fraction of active ingredients are weak acids or bases which offers the possibility to form salts which can again be produced in various solid forms. All these forms will behave differently, and it is of critical importance for the success of a drug to screen for the various forms, characterize them and select the "optimal" solid form.

Sortis pharma is home to scientific leaders and experts in the field who can help you select the best available crystalline candidate. This is where the following physical and chemical properties mainly play a role:

Solubility (dissolution rate)
Stability (chemical and physical)
Melting point
Hygroscopicity
Processability (particle behaviour, flowability)
Ease of preparation
Polymorph landscape complexity and polymorphic transformations

In addition to its impact on chemical and physical properties, new solid forms are also relevant for intellectual property considerations – as solids with superior properties can be patent protected.

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Analytical

Solid state charecterization

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